Perspective: Nutrient bioavailability is the missing ingredient connecting food systems to nutrition security and environmental sustainability

Nicholas, Khristopher M and Tone, Alexandra and Beal, Ty and Zamborain-Mason, Jessica and Eneroth, Hanna and Öhrvik, Veronica and Troell, Max and Golden, Christopher D (2026) Perspective: Nutrient bioavailability is the missing ingredient connecting food systems to nutrition security and environmental sustainability. American Journal of Clinical Nutrition: 101253. ISSN 0002-9165 (In Press)

Abstract

Increasing attention has focused on the capacity of current global food systems to provide accessible, affordable, and sustainable foods to a growing human population, particularly considering ongoing climate and environmental changes. Concerns over global food system dysfunction have led to the development of several initiatives to estimate current and predict future global nutrient supplies based on various climate, production, and demand scenarios, yet none appropriately account for differences in nutrient bioavailability across food groups. As nutrient bioavailability varies substantially between plant-source foods (PSFs) and animal-source foods (ASFs), accounting for these differences has important implications for global nutrient supplies and the environmental costs associated with their production. In this perspective, we highlight the variability in estimated average bioavailability across plant-source foods and animal-source foods for 27 key nutrients and the limited accounting for bioavailability in major studies and nutrition recommendations. We conclude with a discussion of current best practices, highlighting avenues for future research to account for bioavailability and more accurately evaluate and propose nutritionally adequate diets. This perspective suggests that, while existing data limitations should not preclude food systems researchers from accounting for bioavailability, a concerted effort is needed to develop more consistent and representative estimates of bioavailability across a variety of nutrients. [Abstract copyright: Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.]