Effects of Sleep Deprivation on Physical and Mental Health Outcomes : An Umbrella Review

Shah, Arambh Sanjay and Pant, Mitresh Raj and Bommasamudram, Tulasiram and Nayak, Kirtana Raghurama and Roberts, Spencer S. H. and Gallagher, Chloe and Vaishali, K and Edwards, Ben J. and Tod, David and Davis, Fiddy and Pullinger, Samuel A. (2025) Effects of Sleep Deprivation on Physical and Mental Health Outcomes : An Umbrella Review. American Journal of Lifestyle Medicine.

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Abstract

The increasing prevalence of reduced habitual sleep duration presents a significant public health challenge, impacting cardiovascular health, metabolic function and mental well-being. This umbrella review analyses findings from systematic reviews and meta-analyses to comprehensively evaluate the consequences of sleep deprivation (SD) on health. The databases searched included PubMed, Scopus, and Web of Science. Inclusion criteria focused on adult populations with SD and systematic reviews/meta-analyses. Twenty-nine articles were included in the final synthesis, encompassing a variety of health outcomes. Key findings highlight a U-shaped relationship between sleep duration and all-cause mortality, with both short (<7 h) sleep durations associated with increased risks. SD was a significant risk factor for cardiovascular diseases such as hypertension, stroke and coronary heart disease. Alongside heightened risks of metabolic disorders, like obesity and type 2 diabetes. Moreover, SD contributed to elevated anxiety levels, impaired emotional regulation. As well as increased susceptibility to stress and depressive symptoms. This synthesis underscores the critical importance of maintaining recommended sleep duration (typically 7-9 h for adults) to mitigate these health risks effectively. The findings support the need for robust public health interventions aimed at promoting healthy sleep habits to reduce the burden of associated health conditions and enhance overall well-being.