Regioselective silyl installation for arene diversification

Docherty, Jamie (2025) Regioselective silyl installation for arene diversification. Nature Catalysis, 8. pp. 291-292.

Text (Research Briefing)
Research_Briefing.pdf - Accepted Version
Available under License Creative Commons Attribution.
Download (167kB)

Abstract

Using a single ruthenium catalyst, site-selective C–H functionalization methods are developed for the installation of silylmethyl synthetic handles at either ortho or meta positions on diverse arenes, enabling a wide range of downstream transformations. Mechanistic studies highlight that biscyclometallated ruthenium(II) species are key to this reactivity, offering insight for future developments.