Neuronal synchrony during anesthesia:a thalamocortical model

Sheeba, Jane H. and Stefanovska, Aneta and McClintock, Peter V. E. (2008) Neuronal synchrony during anesthesia:a thalamocortical model. Biophysical Journal, 95 (6). pp. 2722-2727. ISSN 0006-3495

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Abstract

There is growing evidence in favor of the temporal-coding hypothesis that temporal correlation of neuronal discharges may serve to bind distributed neuronal activity into unique representations and, in particular, that theta (3.5–7.5 Hz) and delta (0.5 , 3.5 Hz) oscillations facilitate information coding. The theta- and delta-rhythms are shown to be involved in various sleep stages, and during anesthesia, they undergo changes with the depth of anesthesia. We introduce a thalamocortical model of interacting neuronal ensembles to describe phase relationships between theta- and delta-oscillations, especially during deep and light anesthesia. Asymmetric and long-range interactions among the thalamocortical neuronal oscillators are taken into account. The model results are compared with experimental observations. The delta- and theta-activities are found to be separately generated and are governed by the thalamus and cortex, respectively. Changes in the degree of intraensemble and interensemble synchrony imply that the neuronal ensembles inhibit information coding during deep anesthesia and facilitate it during light anesthesia.

Item Type: Journal Article
Journal or Publication Title: Biophysical Journal
Additional Information: Copyright (c) 2008 The Biophysical Society
Uncontrolled Keywords: /dk/atira/pure/researchoutput/libraryofcongress/qc
Subjects:
Departments: Faculty of Science and Technology > Physics
ID Code: 22890
Deposited By: Professor P. V. E. McClintock
Deposited On: 06 Jan 2009 16:44
Refereed?: Yes
Published?: Published
Last Modified: 18 Aug 2019 00:40
URI: https://eprints.lancs.ac.uk/id/eprint/22890

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