Calcium catalysed Strecker-type reactions towards α-aminonitriles †

Basson, Ashley J. and Cameron, Michael P. and McLaughlin, Mark G. (2025) Calcium catalysed Strecker-type reactions towards α-aminonitriles †. Chemical Communications. ISSN 1359-7345

Abstract

We report an operationally simple calcium catalysed Strecker type reaction for the synthesis of α-aminonitriles from readily available N, O-acetals. The reaction is tolerant to a wide range of useful functional groups, including heterocycles, and provides the product in good to excellent yields. Additionally, the reaction does not require the need for anhydrous or air-free conditions, making it a suitable candidate for high throughput experimentation.