Pani, Dr JyotiPrakash and Pandey, Shubham and Pani, Dr Sankarsan and M N Mahendrakar and Katti, Karuna (2013) Estimation of predominant histological alterations in cholecystitis and cholelithiasis of human gallbladder an analytical and statistical study through the approach of routine histochemistry. IOSR Journal of Dental and Medical Sciences, 6 (6). pp. 35-43. ISSN 2279-0853
Full text not available from this repository.Abstract
The purpose of the present study is to compare histological changes in the wall of human gallbladder in abnormal conditions like cholelithiasis & cholecystitis and find out the predominant risk factors for the development of cholelithiasis from primary stage like cholecystitis. To conduct case control study, 60 normal (control group) human gallbladders & 30 abnormal (case group) samples of human gallbladders having cholelithiasis and cholecystitis were obtained and processed & 9 slides were obtained and stained by H&E.. Different histological findings were noted in the various layers of gallbladders. Epithelial hyperplasia, dysplasia with erodification of mucosa and sub epithelial haemorrhages was denoted in both cholelithiasis & cholecystitis. On the behalf of statistical evidence, the present study shows both group case and control are highly significant. Predominant histological alterations were estimated in percentage by counting the number of sign and symtoms or alterations observed in various layers of diseased human gall bladder like cholecystitis and cholelithiasis and the percentage was evaluated by correlating with the normal gallbladder histological representation either/or minimal recessive histological alterations in the normal one. Predominant histological alterations were estimated and found maximum epithelial break was 62.5% in cholelithiasis where as 59.09% in cholecystitis.