Development and Evaluation of Active Case Detection Methods to Support Visceral Leishmaniasis Elimination in India

Dubey, Pushkar and Das, Aritra and Priyamvada, Khushbu and Bindroo, Joy and Mahapatra, Tanmay and Mishra, Prabhas Kumar and Kumar, Ankur and Franco, Ana O. and Rooj, Basab and Sinha, Bikas and Pradhan, Sreya and Banerjee, Indranath and Kumar, Manash and Bano, Nasreen and Kumar, Chandan and Prasad, Chandan and Chakraborty, Parna and Kumar, Rakesh and Kumar, Niraj and Kumar, Aditya and Singh, Abhishek Kumar and Kundan, Kumar and Babu, Sunil and Shah, Hemant and Karthick, Morchan and Roy, Nupur and Gill, Naresh Kumar and Dwivedi, Shweta and Chaudhuri, Indrajit and Hightower, Allen W. and Chapman, Lloyd A.C. and Singh, Chandramani and Sharma, Madan Prasad and Dhingra, Neeraj and Bern, Caryn and Srikantiah, Sridhar (2021) Development and Evaluation of Active Case Detection Methods to Support Visceral Leishmaniasis Elimination in India. Frontiers in cellular and infection microbiology, 11: 648903. ISSN 2235-2988

Abstract

As India moves toward the elimination of visceral leishmaniasis (VL) as a public health problem, comprehensive timely case detection has become increasingly important, in order to reduce the period of infectivity and control outbreaks. During the 2000s, localized research studies suggested that a large percentage of VL cases were never reported in government data. However, assessments conducted from 2013 to 2015 indicated that 85% or more of confirmed cases were eventually captured and reported in surveillance data, albeit with significant delays before diagnosis. Based on methods developed during these assessments, the CARE India team evolved new strategies for active case detection (ACD), applicable at large scale while being sufficiently effective in reducing time to diagnosis. Active case searches are triggered by the report of a confirmed VL case, and comprise two major search mechanisms: 1) case identification based on the index case’s knowledge of other known VL cases and searches in nearby houses (snowballing); and 2) sustained contact over time with a range of private providers, both formal and informal. Simultaneously, house-to-house searches were conducted in 142 villages of 47 blocks during this period. We analyzed data from 5030 VL patients reported in Bihar from January 2018 through July 2019. Of these 3033 were detected passively and 1997 via ACD (15 (0.8%) via house-to-house and 1982 (99.2%) by light touch ACD methods). We constructed multinomial logistic regression models comparing time intervals to diagnosis (30-59, 60-89 and ≥90 days with <30 days as the referent). ACD and younger age were associated with shorter time to diagnosis, while male sex and HIV infection were associated with longer illness durations. The advantage of ACD over PCD was more marked for longer illness durations: the adjusted odds ratios for having illness durations of 30-59, 60-89 and >=90 days compared to the referent of <30 days for ACD vs PCD were 0.88, 0.56 and 0.42 respectively. These ACD strategies not only reduce time to diagnosis, and thus risk of transmission, but also ensure that there is a double check on the proportion of cases actually getting captured. Such a process can supplement passive case detection efforts that must go on, possibly perpetually, even after elimination as a public health problem is achieved.