Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem

Pałasz, A. and Ozimirska, K. and Suszka-Świtek, A. and Bogus, K. and Błaszczyk, I. and Sharma, V. and Pukowiec, M. and Worthington, J.J. and Młynarczuk-Biały, I. and Lipiec-Borowicz, A. (2025) Neuroanatomical mapping of spexin and nesfatin-1-expressing neurons in the human brainstem. Neuropeptides, 109: 102484. ISSN 0143-4179

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Abstract

Neuropeptides are involved in numerous brain activities being able to control a wide spectrum of physiological functions. In recent years, a number of novel pleiotropic regulatory peptides have been discovered in animal brain structures. The purpose of this descriptive neurochemical investigation was to detect the possible expression of the novel multifunctional neuropeptides spexin (SPX) and nesfatin-1 within the human brainstem. Using immunohistochemical and fluorescence techniques, neuroanatomical analysis of the SPX and nesfatin-1 expression and distribution was performed in selected sections of the human midbrain and medulla oblongata. The presence of SPX-positive neurons in the human brainstem was revealed for the first time and previous reports on the expression of nesfatin-1 were additionally confirmed. The research results suggest that SPX and nesfatin-1 are new regulatory neuropeptides of the human brainstem potentially involved in the regulation of key autonomic activities of this brain region.

Item Type:
Journal Article
Journal or Publication Title:
Neuropeptides
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2804
Subjects:
?? cellular and molecular neuroscienceendocrine and autonomic systemsendocrinologyneurology ??
ID Code:
225886
Deposited By:
Deposited On:
25 Nov 2024 10:00
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Dec 2024 01:11