Facilitating the Ethical Sourcing of Donor Hematopoietic Stem Cells for Cell and Gene Therapy Research and Development

Hamad, Lina and Chekar, Choon Key and Anthias, Chloe and Machin, Laura (2024) Facilitating the Ethical Sourcing of Donor Hematopoietic Stem Cells for Cell and Gene Therapy Research and Development. Regenerative Medicine. (In Press)

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Abstract

Aim: Unrelated stem cell donor registries (DRs) are increasingly engaging in the field of cell and gene therapy (CGT). This study aims to explore the values, concerns, needs and expectations of donors and members of the public on donating hematopoietic stem cells (HSCs) for CGT. Methods: Seven focus groups were conducted in 2019 with members of the public, prospective donors and donors on the Anthony Nolan DR in the UK. Results: Participants expressed concerns over increased frequency of donation and incidental findings and required more information on the type of research including the purpose and possible outcomes. Conclusion: Addressing donors’ concerns, needs and expectations on donating cellular materials for CGT research and development is essential to maintaining the highest standards for donor care and safety within this rapidly emerging field.