Individualized survival prediction and surgery recommendation for patients with glioblastoma

Zhu, Enzhao and Wang, Jiayi and Jing, Qi and Shi, Weizhong and Xu, Ziqin and Ai, Pu and Chen, Zhihao and Dai, Zhihao and Shan, Dan and Ai, Zisheng (2024) Individualized survival prediction and surgery recommendation for patients with glioblastoma. Frontiers in Medicine, 11: 1330907. ISSN 2296-858X

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Background: There is a lack of individualized evidence on surgical choices for glioblastoma (GBM) patients. Aim: This study aimed to make individualized treatment recommendations for patients with GBM and to determine the importance of demographic and tumor characteristic variables in the selection of extent of resection. Methods: We proposed Balanced Decision Ensembles (BDE) to make survival predictions and individualized treatment recommendations. We developed several DL models to counterfactually predict the individual treatment effect (ITE) of patients with GBM. We divided the patients into the recommended (Rec.) and anti-recommended groups based on whether their actual treatment was consistent with the model recommendation. Results: The BDE achieved the best recommendation effects (difference in restricted mean survival time (dRMST): 5.90; 95% confidence interval (CI), 4.40–7.39; hazard ratio (HR): 0.71; 95% CI, 0.65–0.77), followed by BITES and DeepSurv. Inverse probability treatment weighting (IPTW)-adjusted HR, IPTW-adjusted OR, natural direct effect, and control direct effect demonstrated better survival outcomes of the Rec. group. Conclusion: The ITE calculation method is crucial, as it may result in better or worse recommendations. Furthermore, the significant protective effects of machine recommendations on survival time and mortality indicate the superiority of the model for application in patients with GBM. Overall, the model identifies patients with tumors located in the right and left frontal and middle temporal lobes, as well as those with larger tumor sizes, as optimal candidates for SpTR.

Item Type:
Journal Article
Journal or Publication Title:
Frontiers in Medicine
?? deep learningtreatment recommendationcausal inferenceglioblastomaneurosurgery ??
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Deposited On:
24 May 2024 10:30
Last Modified:
19 Jun 2024 00:52