A multicenter prospective study of early gestational diabetes mellitus : rates, severity and risk factors based on IADPSG defined fasting glycemia

Olagbuji, Biodun Nelson and Aderoba, Adeniyi Kolade and Olagbuji, Yetunde Winifred and Enikuomehin, Adenike Christianah and Adewole, Ayodele Stephen and Awe, Olayemi Christianah and Akadiri, Olumide (2022) A multicenter prospective study of early gestational diabetes mellitus : rates, severity and risk factors based on IADPSG defined fasting glycemia. International Journal of Gynecology & Obstetrics. ISSN 0020-7292

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Abstract

Objective To describe the epidemiology of early gestational diabetes mellitus (GDM) based on the International Association of Diabetes and Pregnancy Study Groups (IADPSG) defined fasting glycemia. Methods A prospective multicenter study testing fasting venous plasma glucose (FPG) in women aged 18–45 years between 6 and 23+6 weeks of pregnancy in secondary health facilities in Ondo State, Nigeria. Early GDM was defined using the IADPSG threshold for fasting hyperglycemia, and its severity was examined. Potential risk factors for early GDM were assessed using logistic regression analysis. Results Of the 8915 women who underwent FPG testing, the prevalence of early GDM was 12.5% (11.9%–13.3%). Multivariable analysis identified a dose–response association between body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) and early GDM, with a BMI of 35 or more (adjusted odds ratio [aOR] 1.92, 95% confidence interval [CI] 1.03–3.55) associated with early GDM. Primiparity (aOR 1.49, 95% CI 1.25–1.76), multiparity (aOR 1.73, 95% CI 1.47–2.04), and a first-degree family history of diabetes (aOR 1.60, 95% CI 1.27–2.02) were associated with significantly higher odds of early GDM. Conclusion This study established the prevalence, severity and risk factors for early GDM in a specific country that potentially represents a global region with no previous relevant data.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Gynecology & Obstetrics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2729
Subjects:
?? early gestational diabetes mellitusfasting hyperglycemiafasting plasma glucoseovert diabetespregnancyobstetrics and gynaecology ??
ID Code:
220255
Deposited By:
Deposited On:
21 May 2024 11:15
Refereed?:
Yes
Published?:
Published
Last Modified:
21 May 2024 11:15