The trypanosome alternative oxidase : A potential drug target?

Menzies, Stefanie K. and Tulloch, Lindsay B. and Florence, Gordon J. and Smith, Terry K. (2018) The trypanosome alternative oxidase : A potential drug target? Parasitology, 145 (2). pp. 175-183. ISSN 0031-1820

Full text not available from this repository.

Abstract

New drugs against Trypanosoma brucei, the causative agent of Human African Trypanosomiasis, are urgently needed to replace the highly toxic and largely ineffective therapies currently used. The trypanosome alternative oxidase (TAO) is an essential and unique mitochondrial protein in these parasites and is absent from mammalian mitochondria, making it an attractive drug target. The structure and function of the protein are now well characterized, with several inhibitors reported in the literature, which show potential as clinical drug candidates. In this review, we provide an update on the functional activity and structural aspects of TAO. We then discuss TAO inhibitors reported to date, problems encountered with in vivo testing of these compounds, and discuss the future of TAO as a therapeutic target.

Item Type:
Journal Article
Journal or Publication Title:
Parasitology
Additional Information:
Publisher Copyright: Copyright © Cambridge University Press 2016.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400/2405
Subjects:
?? chemotherapydrug discoveryhuman african trypanosomiasissleeping sicknesstrypanosoma bruceitrypanosome alternative oxidaseparasitologyanimal science and zoologyinfectious diseases ??
ID Code:
219876
Deposited By:
Deposited On:
17 May 2024 15:05
Refereed?:
Yes
Published?:
Published
Last Modified:
17 May 2024 15:05