The trypanosome alternative oxidase : A potential drug target?

Menzies, Stefanie K. and Tulloch, Lindsay B. and Florence, Gordon J. and Smith, Terry K. (2018) The trypanosome alternative oxidase : A potential drug target? Parasitology, 145 (2). pp. 175-183. ISSN 0031-1820

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New drugs against Trypanosoma brucei, the causative agent of Human African Trypanosomiasis, are urgently needed to replace the highly toxic and largely ineffective therapies currently used. The trypanosome alternative oxidase (TAO) is an essential and unique mitochondrial protein in these parasites and is absent from mammalian mitochondria, making it an attractive drug target. The structure and function of the protein are now well characterized, with several inhibitors reported in the literature, which show potential as clinical drug candidates. In this review, we provide an update on the functional activity and structural aspects of TAO. We then discuss TAO inhibitors reported to date, problems encountered with in vivo testing of these compounds, and discuss the future of TAO as a therapeutic target.

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Publisher Copyright: Copyright © Cambridge University Press 2016.
Uncontrolled Keywords:
?? chemotherapydrug discoveryhuman african trypanosomiasissleeping sicknesstrypanosoma bruceitrypanosome alternative oxidaseparasitologyanimal science and zoologyinfectious diseases ??
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17 May 2024 15:05
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17 May 2024 15:05