Intracerebral dynamics of sleep arousals : a combined scalp-intracranial EEG study

Wang, Yingqi Laetitia and Avigdor, Tamir and Hannan, Sana and Abdallah, Chifaou and Dubeau, François and Peter-Derex, Laure and Frauscher, Birgit (2024) Intracerebral dynamics of sleep arousals : a combined scalp-intracranial EEG study. Journal of Neuroscience, 44 (16). ISSN 0270-6474

[thumbnail of Clean_R2]
Text (Clean_R2)
Clean_R2.pdf - Accepted Version
Available under License Creative Commons Attribution.

Download (343kB)

Abstract

As an intrinsic component of sleep architecture, sleep arousals represent an intermediate state between sleep and wakefulness and are important for sleep-wake regulation. They are defined in an all-or-none manner, whereas they actually present a wide range of scalp-electroencephalography (EEG) activity patterns. It is poorly understood how these arousals differ in their mechanisms. Stereo-EEG (SEEG) provides the unique opportunity to record intracranial activities in superficial and deep structures in humans. Using combined polysomnography and SEEG, we quantitatively categorized arousals during nonrapid eye movement sleep into slow wave (SW) and non-SW arousals based on whether they co-occurred with a scalp-EEG SW event. We then investigated their intracranial correlates in up to 26 brain regions from 26 patients (12 females). Across both arousal types, intracranial theta, alpha, sigma, and beta activities increased in up to 25 regions ( p  < 0.05; d  = 0.06-0.63), while gamma and high-frequency (HF) activities decreased in up to 18 regions across the five brain lobes ( p  < 0.05; d  = 0.06-0.44). Intracranial delta power widely increased across five lobes during SW arousals ( p  < 0.05 in 22 regions; d  = 0.10-0.39), while it widely decreased during non-SW arousals ( p  < 0.05 in 19 regions; d  = 0.10-0.30). Despite these main patterns, unique activities were observed locally in some regions such as the hippocampus and middle cingulate cortex, indicating spatial heterogeneity of arousal responses. Our results suggest that non-SW arousals correspond to a higher level of brain activation than SW arousals. The decrease in HF activities could potentially explain the absence of awareness and recollection during arousals.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Neuroscience
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2800
Subjects:
?? general neuroscienceneuroscience(all) ??
ID Code:
218414
Deposited By:
Deposited On:
19 Apr 2024 09:35
Refereed?:
Yes
Published?:
Published
Last Modified:
18 Aug 2024 23:54