Selective resonant diffusion of ions in an artificial analogue of a biological filter

Gibby, William A. T. and Barabash, Miraslau L. and Luchinsky, Dmitry G. and McClintock, Peter and Khovanov, Igor A. (2024) Selective resonant diffusion of ions in an artificial analogue of a biological filter. In: 2023 International Conference on Noise and Fluctuations (ICNF) :. IEEE, pp. 1-4. ISBN 9798350330120

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Abstract

We study selective ionic diffusion in a single-walled carbon nanotube (CNT). The wall is charged so as to mimic the structure of the selectivity filters in biological ion channels. We use all-atom molecular dynamics simulations to demonstrate that a charged CNT can closely reproduce many of the selectivity and conductivity properties of the KcsA biological channel. A K+/Na+ selectivity ratio ≳150 and a conduction current Ftable ≳50 pA are demonstrated. It is shown that ionic Coulomb blockade is the key phenomenon underlying the CNT conduction properties. Coulomb blockade theory is used to estimate the excess chemical potential of the ions in the channel and the channel capacitance.

Item Type:
Contribution in Book/Report/Proceedings
Uncontrolled Keywords:
Research Output Funding/yes_externally_funded
Subjects:
?? yes - externally fundedno ??
ID Code:
217187
Deposited By:
Deposited On:
04 Jun 2024 10:45
Refereed?:
Yes
Published?:
Published
Last Modified:
18 Jun 2024 23:48