Achieving continuous manufacturing in lyophilization : Technologies and approaches

Pisano, Roberto and Arsiccio, Andrea and Capozzi, Luigi C. and Trout, Bernhardt L. (2019) Achieving continuous manufacturing in lyophilization : Technologies and approaches. European Journal of Pharmaceutics and Biopharmaceutics, 142. pp. 265-279. ISSN 0939-6411

Abstract

This paper provides an organic overview of the most interesting continuous freeze-drying concepts that have been proposed over the years. Attention has mainly been focused on the field of pharmaceuticals, but some background has also been given on the food industry. This work aims at providing a solid starting point for future research on continuous manufacturing for the freeze-drying of pharmaceuticals.