A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds

Capozzi, Luigi C. and Barresi, Antonello A. and Pisano, Roberto (2019) A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds. Powder Technology, 343. pp. 834-846. ISSN 0032-5910

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Abstract

This work investigates the behavior during freeze-drying of packing structures formed by spray-frozen microparticles. A multi-scale approach is used to study spray freeze-drying, and in particular, mass transfer during primary drying and its duration. The procedure starts with the generation of realistic packings of microparticles using DEM, and CFD simulations are used to determine some relevant characteristics at pore scale, i.e., porosity, tortuosity, the average size of the particle-to-particle voids, and permeability. Finally, these parameters are used to describe mass transfer within the packed-bed. This procedure is used to describe some actual case studies and evaluate drying time and mass transfer resistance within the packing. We also investigated the role of packing structure on freeze-drying by generating packings from monodisperse and Gaussian-polydisperse microparticles, demonstrating that polydispersity increased the mass transfer resistance, and, finally, drying time.

Item Type:
Journal Article
Journal or Publication Title:
Powder Technology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1500/1500
Subjects:
?? freeze-dryinglyophilizationpacked-bedgeneral chemical engineeringchemical engineering(all) ??
ID Code:
215208
Deposited By:
Deposited On:
26 Feb 2024 09:45
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Jul 2024 12:14