Hyper-Dense_Lung_Seg: Multimodal-Fusion-Based Modified U-Net for Lung Tumour Segmentation Using Multimodality of CT-PET Scans

Alshmrani, Goram and Ni, Qiang and Jiang, Richard (2023) Hyper-Dense_Lung_Seg: Multimodal-Fusion-Based Modified U-Net for Lung Tumour Segmentation Using Multimodality of CT-PET Scans. Diagnostics, 13 (22): 3481. ISSN 2075-4418

Abstract

The majority of cancer-related deaths globally are due to lung cancer, which also has the second-highest mortality rate. The segmentation of lung tumours, treatment evaluation, and tumour stage classification have become significantly more accessible with the advent of PET/CT scans. With the advent of PET/CT scans, it is possible to obtain both functioning and anatomic data during a single examination. However, integrating images from different modalities can indeed be time-consuming for medical professionals and remains a challenging task. This challenge arises from several factors, including differences in image acquisition techniques, image resolutions, and the inherent variations in the spectral and temporal data captured by different imaging modalities. Artificial Intelligence (AI) methodologies have shown potential in the automation of image integration and segmentation. To address these challenges, multimodal fusion approach-based U-Net architecture (early fusion, late fusion, dense fusion, hyper-dense fusion, and hyper-dense VGG16 U-Net) are proposed for lung tumour segmentation. Dice scores of 73% show that hyper-dense VGG16 U-Net is superior to the other four proposed models. The proposed method can potentially aid medical professionals in detecting lung cancer at an early stage.