Riddell, Jon and Noureen, Shahzeb Raja and Sedda, Luigi and Glover, James D. and Ho, William K. W. and Bain, Connor A. and Berbeglia, Arianna and Brown, Helen and Anderson, Calum and Chen, Yuhang and Crichton, Michael L. and Yates, Christian A. and Mort, Richard L. and Headon, Denis J. (2023) Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates. Plos Biology, 21 (9). ISSN 1544-9173
Full text not available from this repository.Abstract
Embryonic mesenchymal cells are dispersed within an extracellular matrix but can coalesce to form condensates with key developmental roles. Cells within condensates undergo fate and morphological changes and induce cell fate changes in nearby epithelia to produce structures including hair follicles, feathers, or intestinal villi. Here, by imaging mouse and chicken embryonic skin, we find that mesenchymal cells undergo much of their dispersal in early interphase, in a stereotyped process of displacement driven by 3 hours of rapid and persistent migration followed by a long period of low motility. The cell division plane and the elevated migration speed and persistence of newly born mesenchymal cells are mechanosensitive, aligning with tissue tension, and are reliant on active WNT secretion. This behaviour disperses mesenchymal cells and allows daughters of recent divisions to travel long distances to enter dermal condensates, demonstrating an unanticipated effect of cell cycle subphase on core mesenchymal behaviour.