Cobalt-Catalysed, Ligand-Controlled Regiodivergent Alkene Hydrosilylation

Docherty, Jamie H. and Dominey, Andrew P. and Thomas, Stephen P. (2021) Cobalt-Catalysed, Ligand-Controlled Regiodivergent Alkene Hydrosilylation. Asian Journal of Organic Chemistry, 10 (9). pp. 2379-2384. ISSN 2193-5807

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Abstract

Alkene hydrosilylation is amongst the largest industrial homogenous catalysis processes. Cobalt catalysis offers a sustainable alternative to commonly used platinum catalysts to achieve this transformation. Using two bisiminopyridine cobalt(II) catalysts the regiodivergent hydrosilylation of alkenes has been developed. Variation of pre-catalyst activator and ligand substituents were investigated to enable the controlled, regiodivergent hydrosilylation of both aryl- and alkyl-substituted alkenes with phenylsilane. In contrast to other regiodivergence strategies, excellent regioselectivity for either isomer was achieved using the same ligand class but differing by a single methyl group (ethyl vs isopropyl).