Exocytosis in adrenal chromaffin cells

Burgoyne, R. D. and Morgan, A. and Robinson, I. and Pender, N. and Cheek, T. R. (1993) Exocytosis in adrenal chromaffin cells. Journal of Anatomy, 183 (2). pp. 309-314. ISSN 0021-8782

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Recent advances have led to an increased understanding of the Ca2+-signalling pathway leading to exocytosis in bovine adrenal chromaffin cells. Video-imaging studies have allowed the temporal and spatial aspects of the Ca2+ signal to be investigated in detail. Ca2+ entry at the plasma membrane appears to be crucial for the activation of exocytosis. Ca2+ can enter through the nicotinic channel or characterised voltage-activated channels, or through other poorly defined pathways due to a variety of agonists. Emptying of internal Ca2+ stores is sufficient to activate a Ca2+ entry pathway. The elevation of cytosolic Ca2+ concentration leads to a reorganisation of the cortical actin network and to the triggering of exocytosis. Studies on permeabilised chromaffin cells have resulted in the identification of some of the proteins that control Ca2+-dependent exocytosis. These include the peripheral plasma membrane protein annexin II and the cytosolic proteins, protein kinase C and 14-3-3 proteins (Exol).

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Journal of Anatomy
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06 Sep 2023 09:30
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06 Sep 2023 09:30