Independent regulation of synaptic size and activity by the anaphase-promoting complex

Van Roessel, Peter and Elliott, David A. and Robinson, Iain M. and Prokop, Andreas and Brand, Andrea H. (2004) Independent regulation of synaptic size and activity by the anaphase-promoting complex. Cell, 119 (5). pp. 707-718. ISSN 0092-8674

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Abstract

Neuronal plasticity relies on tightly regulated control of protein levels at synapses. One mechanism to control protein abundance is the ubiquitin-proteasome degradation system. Recent studies have implicated ubiquitin-mediated protein degradation in synaptic development, function, and plasticity, but little is known about the regulatory mechanisms controlling ubiquitylation in neurons. In contrast, ubiquitylation has long been studied as a central regulator of the eukaryotic cell cycle. A critical mediator of cell-cycle transitions, the anaphase-promoting complex/cyclosome (APC/C), is an E3 ubiquitin ligase. Although the APC/C has been detected in several differentiated cell types, a functional role for the complex in postmitotic cells has been elusive. We describe a novel postmitotic role for the APC/C at Drosophila neuromuscular synapses: independent regulation of synaptic growth and synaptic transmission. In neurons, the APC/C controls synaptic size via a downstream effector Liprin-α; in muscles, the APC/C regulates synaptic transmission, controlling the concentration of a postsynaptic glutamate receptor.

Item Type:
Journal Article
Journal or Publication Title:
Cell
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1300
Subjects:
?? general biochemistry,genetics and molecular biologybiochemistry, genetics and molecular biology(all) ??
ID Code:
203304
Deposited By:
Deposited On:
13 Sep 2023 13:55
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Jul 2024 12:06