Healthy and pre-eclamptic placental basal plate lining cells : quantitative comparisons based on confocal laser scanning microscopy

Smith, R K and Ockleford, C D and Byrne, S and Bosio, P and Sanders, R (2004) Healthy and pre-eclamptic placental basal plate lining cells : quantitative comparisons based on confocal laser scanning microscopy. Microscopy Research and Technique, 64 (1). pp. 54-62. ISSN 1059-910X

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Abstract

Immunocytochemical confocal laser scanning microscope images of the monolayer of cells lining the intervillus space at the basal plate of term placentae were analysed using stereology. Immunoreactively-distinct regions of this mosaic layer were measured. In basal plate from healthy pregnancies, trophoblast epithelium occupied 18.91% of the surface area and endothelium 60.81%. In pre-eclampsia the equivalent areas were 15.57% and 67.63%. Acellular fibrinoid covers the remaining area and this component decreases in area in pre-eclampsia. The statistically significant increase in the cellular endothelial compartment may be relevant to the hypertensive pathology of pre-eclampsia as endothelial signalling plays a major role in regulation of blood pressure. (C) 2004 Wiley-Liss, Inc.

Item Type:
Journal Article
Journal or Publication Title:
Microscopy Research and Technique
Additional Information:
RAE_import_type : Journal article RAE_uoa_type : Allied Health Professions and Studies
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2702
Subjects:
?? pre-eclampsia • basal plate • intervillus space • caveolin-1 • endothelial cells • trophoblast invasion • cytokeratin expression • placental developmentanatomyinstrumentationmedical laboratory technologyhistologyr medicine (general) ??
ID Code:
1999
Deposited By:
Deposited On:
05 Feb 2010 10:28
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 09:48