Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Birch, Joanna L. and Coull, Barry J. and Spender, Lindsay C. and Watt, Courtney and Willison, Alice and Syed, Nelofer and Chalmers, Anthony J. and Hossain-Ibrahim, M. Kismet and Inman, Gareth J. (2020) Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma. Cellular Signalling, 72: 109638. p. 109638. ISSN 0898-6568

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Abstract

Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14–15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional cytokine TGFβ plays fundamental roles in development, adult tissue homeostasis, tissue wound repair and immune responses. Dysfunction of TGFβ signalling has been implicated in both the development and progression of many tumour types including GBM, thereby potentially providing an actionable target for its treatment. This review will examine TGFβ signalling mechanisms and their role in the development and progression of GBM. The targeting of TGFβ signalling using a variety of approaches including the TGFβ binding protein Decorin will be highlighted as attractive therapeutic strategies.

Item Type:
Journal Article
Journal or Publication Title:
Cellular Signalling
Additional Information:
Funding Information: The authors acknowledge grants from Cancer Research UK (A29802) and Tenovus Tayside , UK. Publisher Copyright: © 2020 Elsevier Inc.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1307
Subjects:
?? decoringlioblastomatransforming growth factor betacell biology ??
ID Code:
196543
Deposited By:
Deposited On:
06 Jul 2023 08:55
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 23:54