Pyridoxine in atopic dermatitis.

Mabin, D. C. and Hollis, S. and Lockwood, J. and David, T. J. (1995) Pyridoxine in atopic dermatitis. British Journal of Dermatology, 133 (5). pp. 764-767. ISSN 1365-2133

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Summary A previous study has reported benefit when pyridoxine hydrochloride was given to patients with atopic dermatitis. To investigate this in children, we performed a randomized, double-blind, parallel-group, placebo-controlled trial. Forty-eight children with moderate or severe atopic dermatitis were recruited and, of those who completed the study, 19 received pyridoxine hydrochloride 50 mg once daily for 4 weeks and 22 received placebo. Disease activity was monitored by clinical severity scores measuring the extent and degrees of erythema recorded by the investigator and symptom scores (daytime itch and nocturnal sleep disturbance) recorded by parents. There was no statistically significant difference between the two groups at the end of treatment. We have been unable to demonstrate clinical benefit from pyridoxine supplementation in children with atopic dermatitis.

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Journal Article
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British Journal of Dermatology
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13 Nov 2008 14:43
Last Modified:
19 Sep 2023 00:13