A practical synthesis of 1,3-disubstituted cubane derivatives †

Kazi, Nahin and Aublette, Marine C. and Allinson, Sarah L. and Coote, Susannah C. (2023) A practical synthesis of 1,3-disubstituted cubane derivatives †. Chemical Communications, 59 (51). pp. 7971-7973. ISSN 1359-7345

Abstract

A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. The approach exploits a readily available enone intermediate previously used for the synthesis of 1,4-disubstituted cubanes, by introducing a novel Wharton transposition to access useful quantities of 1,3-disubstituted cubanes for diverse applications.