The emerging role of fatty acid binding protein 5 (FABP5) in cancers

Warren, William George and Osborn, Myles and Yates, Andy and Wright, Karen and O'Sullivan, Saoirse E (2023) The emerging role of fatty acid binding protein 5 (FABP5) in cancers. Drug Discovery Today, 28 (7). ISSN 1359-6446

Full text not available from this repository.


Fatty acid binding protein 5 (FABP5, or epidermal FABP) is an intracellular chaperone of fatty acid molecules that regulates lipid metabolism and cell growth. In patient-derived tumours, FABP5 expression is increased up to tenfold, often co-expressed with other cancer-related proteins. High tumoral FABP5 expression is associated with poor prognosis. FABP5 activates transcription factors (TFs) leading to increased expression of proteins involved in tumorigenesis. Genetic and pharmacological preclinical studies show that inhibiting FABP5 reduces protumoral markers, whereas elevation of FABP5 promotes tumour growth and spread. Thus, FABP5 might be a valid target for novel therapeutics. The evidence base is currently strongest for liver, prostate, breast, and brain cancers, and squamous cell carcinoma (SCC), which could represent relevant patient populations for any drug discovery programme.

Item Type:
Journal Article
Journal or Publication Title:
Drug Discovery Today
Uncontrolled Keywords:
ID Code:
Deposited By:
Deposited On:
31 May 2023 15:10
Last Modified:
18 Sep 2023 02:14