Analysis of patchclamp recordings:model-free multiscale methods and software

Pein, Florian and Eltzner, Benjamin and Munk, Axel (2021) Analysis of patchclamp recordings:model-free multiscale methods and software. European Biophysics Journal, 50 (2). pp. 187-209. ISSN 0175-7571

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Analysis of patchclamp recordings is often a challenging issue. We give practical guidance how such recordings can be analyzed using the model-free multiscale idealization methodology JSMURF, JULES, and HILDE. We provide an operational manual how to use the accompanying software available as an R-package and as a graphical user interface. This includes selection of the right approach and tuning of parameters. We also discuss advantages and disadvantages of model-free approaches in comparison to hidden Markov model approaches and explain how they complement each other.

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Journal Article
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European Biophysics Journal
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24 May 2023 15:40
Last Modified:
17 Sep 2023 03:10