Mortality and cancer incidence in UK military veterans involved in human experiments at Porton Down : 48-year follow-up

Archer, Gemma and Keegan, Thomas J and Carpenter, Lucy M and Venables, Katherine M and Fear, Nicola T (2023) Mortality and cancer incidence in UK military veterans involved in human experiments at Porton Down : 48-year follow-up. International Journal of Epidemiology, 52 (4). pp. 1025-1034. ISSN 0300-5771

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BACKGROUND: We investigated whether military personnel involved in chemical warfare agent research at Porton Down had increased rates of mortality or cancer incidence. METHODS: This was a historical cohort study comprising male UK veterans who participated in the 'Service Volunteer Programme', 1941-89, identified from Porton Down experiment books, and a comparison group of similar 'non-Porton Down' veterans identified from military personnel files. Of 19 233 records retrieved for each group, 18 133 (94%) Porton Down and 17 591 (92%) non-Porton Down were included in our analytical sample. Mortality and cancer incidence data were obtained from national registries up to December 2019. RESULTS: Over a median follow-up of 48.1 years, 10 935 Porton Down veterans (60.3%) and 10 658 non-Porton Down veterans (60.6%) had died. After adjustment for age, year of birth and military service characteristics, overall, Porton Down veterans had a 6% higher rate of all-cause mortality compared with non-Porton Down veterans [hazard ratio (HR) = 1.06, 95% confidence interval (CI) 1.03-1.09]. For cause-specific mortality, Porton Down veterans had higher rates of death from genitourinary diseases (HR = 1.34, 95% CI 1.05-1.70) and deaths attributable to alcohol (HR = 1.44, 95% CI 1.07-1.94), with weaker associations observed for deaths from infectious and parasitic diseases (HR = 1.32, 95% CI 0.99-1.78), lung cancer (HR = 1.10, 95% CI 1.01-1.20) and external causes (HR = 1.15, 95% CI 1.00-1.32). Associations with all-cause mortality were stronger for veterans who attended Porton Down between 1960 and 1964 (HR = 1.34, 95% CI 1.19-1.50); likelihood-ratio test, P = 0.006. There was no association between attendance at Porton Down and overall cancer incidence (HR = 1.00, 95% CI 0.95-1.03). CONCLUSIONS: Overall, mortality rates were slightly higher in Porton Down veterans, but there was no difference in cancer incidence. Associations for mortality were stronger in Porton Down veterans who attended in the early 1960s.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Epidemiology
Additional Information:
© The Author(s) 2023. Published by Oxford University Press on behalf of the International Epidemiological Association.
Uncontrolled Keywords:
Research Output Funding/yes_externally_funded
?? veteransmilitary healthcohort studiesmortalitycancer incidencechemical exposuretoxicologyyes - externally fundedyesgeneral medicineepidemiology ??
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Deposited On:
16 May 2023 09:20
Last Modified:
15 Jul 2024 23:48