Additive isotonic models in epidemiology.

Morton-Jones, A. J. and Diggle, Peter J. and Parker, L. and Dickinson, H. O. and Binks, K. (2000) Additive isotonic models in epidemiology. Statistics in Medicine, 19 (6). pp. 849-859. ISSN 1097-0258

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Stone's method for assessing disease risk around a point source through isotonic regression is routinely used in spatial epidemiology. It is useful in situations where the relationship of risk with exposure (distance being commonly used as a surrogate variable) is assumed monotonic but otherwise of unknown form. This paper extends this method to non-spatial epidemiology, where typically two or more risk factors are present. The methodology described is based on the additive isotonic model approach of Bacchetti; versions appropriate to count (Poisson) data and case-control (binomial) data are described. In both cases, adjustment for covariates is incorporated, and a Monte Carlo method of hypothesis testing and interval estimation is presented. The methodology is illustrated through a case-control example concerning the analysis of the possible effect of preconceptional external ionizing radiation doses on the sex ratio at birth among children of fathers working at the Sellafield nuclear installation, Cumbria, U.K.

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Statistics in Medicine
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20 Nov 2008 14:23
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19 Sep 2023 00:13