Taylor, A. and Budd, D.C. and Shih, B. and Seifert, O. and Beaton, A. and Wright, T. and Dempsey, M. and Kelly, F. and Egerton, J. and Marshall, R.P. and Aston, N. and Bayat, A. (2017) Transforming growth factor beta gene signatures are spatially enriched in keloid tissue biopsies and ex vivo-cultured keloid fibroblasts. Acta dermato-venereologica, 97 (1). pp. 10-16. ISSN 1651-2057
Full text not available from this repository.Abstract
The keloid lesion is recognised as a spatially heterogeneous mass both in cellular and acellular composition and biological activity. Here, we have utilised a bioinformatic approach to determine whether this spatial heterogeneity is also evident at the molecular level and to identify key upstream regulators of signalling pathways enriched in the lesion in a spatially-restricted manner. Differentially expressed genes (20% change, p