Transforming growth factor beta gene signatures are spatially enriched in keloid tissue biopsies and ex vivo-cultured keloid fibroblasts

Taylor, A. and Budd, D.C. and Shih, B. and Seifert, O. and Beaton, A. and Wright, T. and Dempsey, M. and Kelly, F. and Egerton, J. and Marshall, R.P. and Aston, N. and Bayat, A. (2017) Transforming growth factor beta gene signatures are spatially enriched in keloid tissue biopsies and ex vivo-cultured keloid fibroblasts. Acta dermato-venereologica, 97 (1). pp. 10-16. ISSN 1651-2057

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Abstract

The keloid lesion is recognised as a spatially heterogeneous mass both in cellular and acellular composition and biological activity. Here, we have utilised a bioinformatic approach to determine whether this spatial heterogeneity is also evident at the molecular level and to identify key upstream regulators of signalling pathways enriched in the lesion in a spatially-restricted manner. Differentially expressed genes (20% change, p

Item Type:
Journal Article
Journal or Publication Title:
Acta dermato-venereologica
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2708
Subjects:
?? dermatology ??
ID Code:
192118
Deposited By:
Deposited On:
10 May 2023 08:20
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 23:45