Dopamine and impairment at the executive level.

Crawford, Trevor J. and Broerse, Annelies and den Boer, Jans A. (1999) Dopamine and impairment at the executive level. Behavioral and Brain Sciences, 22 (4). pp. 678-679. ISSN 0140-525X

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Patients with schizophrenia have an impairment in the inhibition of reflexive saccades, as a consequence of a functional impairment of the prefrontal cortex, which has not yet been encapsulated in terms of a formal model. A number of novel and testable hypotheses can be generated from the framework proposed by Findlay & Walker that will stimulate further research. Their framework therefore marks an important step in the development of a comprehensive functional model of saccadic eye movements. Further advances will be assisted by (1) a recognition of important distinctions in the executive control of volitional saccades and (2) addressing the capacity for cross-model integration of spatial information in the generation of the spatial properties of saccadic eye movements.

Item Type:
Journal Article
Journal or Publication Title:
Behavioral and Brain Sciences
Additional Information: The final, definitive version of this article has been published in the Journal, Behavioral and Brain Sciences, 22 (4), pp 678-679 1999, © 1999 Cambridge University Press.
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05 Nov 2008 14:26
Last Modified:
21 Mar 2023 00:57