HNRNPA2B1-Mediated MicroRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer

Li, Yiling and Li, Kexin and Lou, Xiaoying and Wu, Yue and Seery, Samuel and Xu, Danfei and Pei, Yuqing and Qian, Benheng and Wu, Yuxin and Liang, Shuang and Wu, Kui and Cui, Wei (2023) HNRNPA2B1-Mediated MicroRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer. Cancers, 15 (4): 1367. ISSN 2072-6694

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Abstract

MicroRNA-92a (miR-92a) may serve as a novel promising biomarker in multiple cancers, including colorectal cancer (CRC); however, the diagnostic accuracy and the underlying molecular mechanism of miR-92a in CRC is poorly understood. We first carried out meta-analysis and found that serum/plasma miR-92a yield better diagnostic efficacy when compared to stool samples and CRC tissues, and this finding was validated by our independent study through stool sample. Multiple bioinformatics assay indicated that miR-92a expression was positively correlated with heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) expression and closely related with the clinical characteristics of CRC. Experimental evidence showed that knockdown of HNRNPA2B1 could significantly decrease miR-92a expression and secretion in RKO cells. HNRNPA2B1 mediated miR-92a via m6A RNA modification. These findings indicate that HNRNPA2B1-m6A RNA modification-derived MicroRNA-92a upregulation and section from the local CRC acts a candidate noninvasive serum biomarker in colorectal cancer. Our study provides a novel insight into miR-92a mechanisms in relation to both expression and secretion for CRC diagnosis.

Item Type:
Journal Article
Journal or Publication Title:
Cancers
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2730
Subjects:
?? colorectal cancermir-92abiomarkerhnrnpa2b1n6-methyladenosine (m6a)oncologycancer research ??
ID Code:
188244
Deposited By:
Deposited On:
06 Mar 2023 14:10
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 23:38