Creating 3D objects with integrated electronics via multiphoton fabrication in vitro and in vivo

Baldock, Sara and Kevin, Punarja and Harper, Garry and Griffin, Rebecca and Genedy, Hussein and Fong, James and Zhao, Zhiyi and Zhang, Zijian and Shen, Yaochun and Lin, Hungyen and Au, Catherine and Martin, Jack and Ashton, Mark and Haskew, Mathew and Stewart, Beverley and Efremova, Olga and Esfahani, Reza and Emsley, Hedley and Appleby, John and Cheneler, David and Cummings, Damian M. and Benedetto, Alex and Hardy, John (2023) Creating 3D objects with integrated electronics via multiphoton fabrication in vitro and in vivo. Advanced Materials Technologies. ISSN 2365-709X

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3D objects with integrated electronics were produced using an additive manufacturing approach relying on multiphoton fabrication (direct laser writing, DLW). Conducting polymer-based structures (with micrometer-millimeter scale features) were printed within exemplar matrices, including an elastomer (polydimethylsiloxane, PDMS) widely investigated for biomedical applications. The fidelity of the printing process in PDMS was assessed by optical coherence tomography, and the conducting polymer structures were demonstrated to be capable of stimulating mouse brain tissue in vitro. Furthermore, the applicability of the approach to printing structures in vivo was demonstrated in live nematodes (Caenorhabditis elegans). These results highlight the potential for such additive manufacturing approaches to produce next-generation advanced material technologies, notably integrated electronics for technical and medical applications (e.g., human-computer interfaces).

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Journal Article
Journal or Publication Title:
Advanced Materials Technologies
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Deposited On:
21 Feb 2023 11:35
Last Modified:
13 Mar 2023 09:50