Hydroxy- and Alkoxycyclizations of Enynes Catalyzed by Platinum(II) Chloride

Echavarren, Antonio M. and Munoz-Herranz, Maria and Méndez, María and Nevado, Cristina and Cárdenas, Diego J. (2003) Hydroxy- and Alkoxycyclizations of Enynes Catalyzed by Platinum(II) Chloride. SYNTHESIS (18). pp. 2898-2902. ISSN 0039-7881

Abstract

The cyclization of 1-en-6-ynes catalyzed by PtCl2 in the presence of water or alcohols affords five or six-membered ring carbocycles containing hydroxy or alkoxy functional groups in high yields. The alkoxycyclizations can also be performed with AuCl3 as catalyst. The reaction is stereospecific, atom-economical, and takes place in environmentally friendly solvents.