Highly water-stable bimetallic organic framework MgCu-MOF74 for inhibiting bacterial infection and promoting bone regeneration

Liu, Jiamin and Tan, Yanni and Shen, Erdong and Liu, Bo and Tian, Yingtao and Liang, Luxin and Yan, Xinxin and Wu, Hong (2022) Highly water-stable bimetallic organic framework MgCu-MOF74 for inhibiting bacterial infection and promoting bone regeneration. Biomedical Materials, 17 (6): 065026. ISSN 1748-6041

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Abstract

As a typical metal-organic framework (MOF), Mg-MOF74 can release biocompatible Mg 2+when the framework is degraded, and it has the potential to be used as filler in the field of bone tissue engineering. However, Mg-MOF74 has poor stability in aqueous environment and limited antibacterial ability, which limit its further development and applications. In this work, MgCu-MOF74 particles with different Cu content were synthesized through a facile one-step hydrothermal method. The physicochemical properties and water stability of the synthesized powders were characterized. The osteogenic potential of the MgCu-MOF74 particles on human osteogenic sarcoma cells (SaOS-2) was evaluated. The hybrid MgCu-MOF74 exhibited favorable water stability. These results indicated that MgCu-MOF74 enhanced cellular viability, alkaline phosphatase levels, collagen (COL) synthesis and osteogenesis-related gene expression. Moreover, the samples doped with Cu 2+were more sensitive to the acidic microenvironment produced by bacteria, and exhibited stronger antibacterial ability than Mg-MOF74. In conclusion, MgCu-MOF-74 with good water stability, osteogenic ability and antibacterial ability, which could be attributed to the doping of Cu 2+. Hence, MgCu-MOF74 shows great potential as a novel medical bio-functional fillers for the treatment of bone defects.

Item Type:
Journal Article
Journal or Publication Title:
Biomedical Materials
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2200/2211
Subjects:
?? bacterial infectionsosteogenesismagnesium metal organic framework-74metal-organic frameworks - pharmacologyanti-bacterial agents - chemistrytissue scaffolds - chemistryhumanscopperbone regenerationbone repairosteogenesisantibacterialwatermechanics of mate ??
ID Code:
185547
Deposited By:
Deposited On:
01 Feb 2023 15:10
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 23:19