Biosurfactants as foaming agents in calcium phosphate bone cements

Cichon, Ewelina and Czechowska, Joanna and Krok-Borkowicz, Malgorzata and Allinson, Sarah and Stepien, Karolina and Smith, Alan and Pamula, Elzbieta and Douglas, Timothy and Zima, Aneta (2023) Biosurfactants as foaming agents in calcium phosphate bone cements. Biomaterials Advances, 145: 213273. ISSN 2772-9508

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Abstract

The idea of using biosurfactants to obtain highly porous, foamed calcium phosphate cements (fCPCs) is novel. The popularity of these compounds is mainly attributed to their biological activity such as anticancer or antibacterial properties. In our study, it was investigated how the functionalization of cements, based on α-tricalcium phosphate (α-TCP), with non-ionic biosurfactants such as sucrose ester S0112 and saponin from Quillaja bark affected the physicochemical as well as biological properties of cement-type materials. Foaming with these selected surface active agents led to highly porous fCPCs (open porosity >60 vol%) with compressive strength values ranging from 0.2 to 3.3 MPa and did not influence negatively the bioactive potential of the cements. Results showed that the sucrose ester had a positive effect on all studied cell types (osteosarcoma cell line MG-63 and preosteoblasts MC3T3-E1), while the effect of the saponin differed depending on the origin of the cells (cancerous or non-cancerous). The obtained results shed new light on the use of biosurfactants as additives to CPCs and pave the way for further studies, especially in vivo.

Item Type:
Journal Article
Journal or Publication Title:
Biomaterials Advances
Additional Information:
This is the author’s version of a work that was accepted for publication in Biomaterials Advances. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biomaterials Advances, 145, 2023 DOI: 10.1016/j.bioadv.2022.213273
Subjects:
?? bone cementsbiosurfactantscalcium phosphatesporositynonionic surfactants ??
ID Code:
182349
Deposited By:
Deposited On:
05 Jan 2023 15:55
Refereed?:
Yes
Published?:
Published
Last Modified:
28 May 2024 11:27