Potent antibacterial activity of MXene–functionalized graphene nanocomposites

Salmi, Mohammed and Ahmed, Usman and Aslfattahi, Navid and Rahman, Saidur and Hardy, John and Anwar, Ayaz (2022) Potent antibacterial activity of MXene–functionalized graphene nanocomposites. RSC Advances, 12 (51). pp. 33142-33155. ISSN 2046-2069

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Two dimensional (2D) nanomaterials display properties with significant biological utility (e.g., antimicrobial activity). In this study, MXene–functionalized graphene (FG) nanocomposites with Ti3C2Tx in varying ratios (FG : Ti3C2Tx, 25 : 75%, 50 : 50%, and 75 : 25%) were prepared and characterized via scanning electron microscopy, scanning electron microscopy-energy dispersive X-ray (SEM-EDX), high-resolution transmission electron microscopy (HRTEM), and zeta potential analysis. Their cytotoxicity was assessed using immortalized human keratinocytes (HaCaT) cells at three different timepoints, and antibacterial activity was assessed using Gram-positive Methicillin resistant Staphylococcus aureus, MRSA, and Gram-negative neuro-pathogenic Escherichia coli K1 (E. coli K1) in vitro. The nanomaterials and composites displayed potent antibacterial effects against both types of bacteria and low cytotoxicity against HaCaT cells at 200 μg mL−1, which is promising for their utilization for biomedical applications.

Item Type:
Journal Article
Journal or Publication Title:
RSC Advances
Uncontrolled Keywords:
?? chemistry(all)biomaterialschemical engineering(all)fst keywords:sdg 3 - good health and well-being ??
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Deposited On:
29 Nov 2022 15:25
Last Modified:
14 Dec 2023 01:47