Risk-Based Colposcopy for Cervical Precancer Detection:A Cross-Sectional Multicenter Study in China

Xue, Peng and Seery, Samuel and Li, Qing and Jiang, Yu and Qiao, Youlin (2022) Risk-Based Colposcopy for Cervical Precancer Detection:A Cross-Sectional Multicenter Study in China. Diagnostics, 12 (11). ISSN 2075-4418

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Abstract

Recently published guidelines depend upon screening for cervical precancer risk stratification; however, colposcopy provides key information. There is no data from developing countries that could be used comparatively. Therefore, we assessed the potential benefits of intercalating colposcopic impressions with screening results to detect cervical precancers through a multicenter, cross-sectional study of a Chinese population. Anonymized data from 6012 women with cytologic assessment, human papillomavirus (HPV) testing, colposcopic impressions, and histological results were analyzed. Univariate and multivariate analysis showed that high-grade squamous intraepithelial lesion (HSIL) cytology, HPV16/18+, and/or high-grade colposcopic impressions markedly increased cervical precancer risk, while high-grade colposcopic impressions were associated with the highest risk. The risk of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) ranged from 0% for normal/benign colposcopic impressions, 19% increased risk of CIN3+, even in participants without HSIL+ cytology and/or HPV16/18+. Regardless of screening outcomes, normal/benign colposcopic impressions were associated with the lowest risk of CIN3+ (

Item Type:
Journal Article
Journal or Publication Title:
Diagnostics
Subjects:
ID Code:
178746
Deposited By:
Deposited On:
07 Nov 2022 13:10
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Nov 2022 12:02