Infrared Spectroscopy of Urine for the Non-Invasive Detection of Endometrial Cancer

Ramirez, Carlos A. Meza and Stringfellow, Helen and Naik, Raj and Crosbie, Emma J. and Paraskevaidi, Maria and Rehman, Ihtesham U. and Martin-Hirsch, Pierre (2022) Infrared Spectroscopy of Urine for the Non-Invasive Detection of Endometrial Cancer. Cancers, 14 (20). ISSN 2072-6694

Full text not available from this repository.

Abstract

Current triage for women with post-menopausal bleeding (PMB) to diagnose endometrial cancer rely on specialist referral for intimate tests to sequentially image, visualise and sample the endometrium. A point-of-care non-invasive triage tool with an instant readout could provide immediate reassurance for low-risk symptomatic women, whilst fast-tracking high-risk women for urgent intrauterine investigations. This study assessed the potential for infrared (IR) spectroscopy and attenuated total reflection (ATR) technology coupled with chemometric analysis of the resulting spectra for endometrial cancer detection in urine samples. Standardised urine collection and processing protocols were developed to ensure spectroscopic differences between cases and controls reflected cancer status. Urine spectroscopy distinguished endometrial cancer (n = 109) from benign gynaecological conditions (n = 110) with a sensitivity of 98% and specificity of 97%. If confirmed in subsequent low prevalence studies embedded in PMB clinics, this novel endometrial cancer detection tool could transform clinical practice by accurately selecting women with malignant pathology for urgent diagnostic work up whilst safely reassuring those without.

Item Type:
Journal Article
Journal or Publication Title:
Cancers
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1306
Subjects:
ID Code:
178060
Deposited By:
Deposited On:
26 Oct 2022 07:25
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Nov 2022 11:59