Long-Term Outcomes for Chinese COPD Patients After PCI : A Propensity Score Matched, Double-Cohort Study

Zheng, Yitian and Qi, Yu and Seery, Samuel and Wang, Wenyao and Zhao, Wei and Shen, Tao and Zhou, Lequn and Yang, Jie and Li, Chen and Wang, Xuliang and Gao, Jun and Meng, Xiangbin and Dong, Erdan and Tang, Yi-Da (2022) Long-Term Outcomes for Chinese COPD Patients After PCI : A Propensity Score Matched, Double-Cohort Study. Frontiers in Cardiovascular Medicine, 9: 827635. ISSN 2297-055X

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Objectives: The aim of this study was to analyze long-term outcomes of Chinese coronary artery disease (CAD) patients with (and without) chronic obstructive pulmonary disease (COPD) after percutaneous coronary intervention (PCI). Background: Chronic obstructive pulmonary disease is a chronic condition which often develops in conjunction with CAD. PCI is a core therapy for CAD, although we still need to understand CAD-COPD outcomes and to identify factors that influence prognoses, across ethnicities. Methods: This double-cohort study involved 12,343 Chinese CAD patients who received PCI. Baseline characteristics were collected in two independent, specialty centers. Propensity-score matching was performed to control confounding factors, using a nearest neighbor matching method within a 0.02 caliper and on a propensity score scale of 0.1 for each center. Comorbid CAD-COPD cases were compared to non-COPD patients in terms of major adverse cardiac events (MACEs). Results: Patients with COPD were generally older than those without COPD (65.4 ± 9.2 vs. 58.2 ± 10.3, p < 0.001). There were no significant differences in the end points between COPD and non-COPD groups after PCI (All p > 0.05); however, the incidence of MACEs increased after 450 days. Further subgroup analysis suggests that COPD is approximately four times more prevalent among those aged over 75 years (HR, 3.818; 95%CI, 1.10–13.29; p = 0.027) and those aged below 55 years (HR = 4.254; 95% CI, 1.55–11.72; p = 0.003). Conclusion: Having COPD does not appear to have a significant impact on CAD outcomes 2 years after PCI, and beyond. However, an increasing number of MACEs was observed after 450 days, which suggests that there may be a double-stage effect of COPD on PCI prognosis. There is a need for focused comorbidity management, specifically for those aged below 55 years and above 75 years.

Item Type:
Journal Article
Journal or Publication Title:
Frontiers in Cardiovascular Medicine
?? cardiovascular medicinechronic obstructive pulmonary diseasecoronary artery diseasepercutaneous coronary interventionoutcomesaging ??
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Deposited On:
19 Jul 2022 09:00
Last Modified:
28 Nov 2023 11:40