The silicon trypanosome: a test case of iterative model extension in systems biology.

Achcar, F and Fadda, A and Haanstra, JR and Kerkhoven, EJ and Kim, DH and Leroux, AE and Papamarkou, T and Rojas, F and Bakker, BM and Barrett, MP and Clayton, C and Girolami, M and Krauth-Siegel, R.L. and Matthews, Keith R. and Breitling, R (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64. pp. 115-143. ISSN 0065-2911

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The African trypanosome, Trypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology.

Item Type:
Journal Article
Journal or Publication Title:
Advances in Microbial Physiology
Uncontrolled Keywords:
?? dynamic modellinguncertaintymetabolomicstranscriptomicstrypanosoma bruceisystems biologydifferential equationsmicrobiologyphysiology ??
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Deposited On:
12 Jul 2022 08:10
Last Modified:
15 Jul 2024 22:47