Synthesis of 2-substituted benzimidazoles and 1,5-disubstituted benzodiazepines on alumina and zirconia catalysts

Rekha, M. and Hamza, A. and Venugopal, B.R. and Nagaraju, N. (2012) Synthesis of 2-substituted benzimidazoles and 1,5-disubstituted benzodiazepines on alumina and zirconia catalysts. Cuihua Xuebao/Chinese Journal of Catalysis, 33 (2-3). pp. 439-446. ISSN 0253-9837

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Abstract

In this study, alumina, zirconia, manganese oxide/alumina, and manganese oxide/zirconia have been investigated for their catalytic activity in the condensation reaction between o-phenylenediamine and an aldehyde or a ketone to synthesise 2-substituted benzimidazoles and 1,5-disubstituted benzodiazepines respectively. Surface area, surface acidity, and morphology of the catalysts have been analysed and correlated with their catalytic activity. The isolated yields of 2-substituted benzimidazoles and 1,5-disubstituted benzodiazepines are in the range of 30% to 95%. A good correlation between the amount of surface acid sites as well as the surface morphology of the catalysts and the catalytic activity has been observed. This method has been found to be simple and economical. The solid supports could be regenerated and reused without much loss in their activity. Further, the solid supports have been also found to be effective as general catalysts in the condensation of o-phenylenediamine with other substituted aldehydes and ketones.

Item Type:
Journal Article
Journal or Publication Title:
Cuihua Xuebao/Chinese Journal of Catalysis
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1500/1503
Subjects:
ID Code:
171772
Deposited By:
Deposited On:
15 Jun 2022 14:40
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Nov 2022 11:33