Aberrant IL-17 levels in rodent models of Autism Spectrum Disorder : a systematic review

Thawley, Alexandra Jade and Veneziani, Luciana and Rabelo-da-Ponte, Francisco Diego and Riederer, Ingo and Mendes Da Cruz, Daniella Areas and Bambini Junior, Victorio (2022) Aberrant IL-17 levels in rodent models of Autism Spectrum Disorder : a systematic review. Frontiers in Immunology, 13: 874064. ISSN 1664-3224

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Abstract

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-17A (IL-17A or IL-17), have been implicated as part of immune alterations that may contribute to this outcome. In this context, rodent models have helped elucidate the role of T-cell activation and IL-17 secretion in the pathogenesis of ASD. Regarding the preclinical findings, the data available is contradictory in offspring but not in the pregnant dams, pointing to IL-17 as one of the main drivers of altered behaviour in some models ASD, whilst there are no alterations described in IL-17 levels in others. To address this gap in the literature, a systematic review of altered IL-17 levels in rodent models of ASD was conducted. In total, 28 studies that explored IL-17 levels were included and observed that this cytokine was generally increased among the different models of ASD. The data compiled in this review can help the choice of animal models to study the role of cytokines in the development of ASD, seeking a parallel with immune alterations observed in individuals with this condition. Systematic Review Registration: PROSPERO, identifier CRD42022306558.