Exploring ‘quality’ in cord blood transfusion: uncertainties, bionetworks, and collaborations

Lonergan, Bradley and Williams, Richard and Matsushige, Takuya and Machin, Laura (2022) Exploring ‘quality’ in cord blood transfusion: uncertainties, bionetworks, and collaborations. New Genetics and Society. ISSN 1463-6778 (In Press)

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Abstract

Umbilical cord blood unit (CBU) ‘quantity’ continues to grow internationally, whilst cord blood transplantation (CBT) ‘quality’ remains poorly defined and subject to uncertainty. CBT ‘quality’ is affected by both the product (i.e. CBUs) and CBT processes, with ‘best practice’ varying across countries. To improve overall CBT ‘quality’, we need to better understand the uncertainty associated with CBUs and CBT processes, and how staff manage it. In this qualitative study, we conducted in-depth semi-structured interviews with individuals working in CBT in UK and Japan. We found that understanding of CBT quality by the cord blood community, is underpinned by the quality of the CBU, the expertise and collaboration of scientific and clinical stakeholders, trust in collection and testing processes and international accreditation. Importantly, we found that local and individual experience is used to manage uncertainty within CBT, and we propose that selection guidelines should acknowledge the extent of uncertainty in decision-making.

Item Type:
Journal Article
Journal or Publication Title:
New Genetics and Society
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2719
Subjects:
ID Code:
170088
Deposited By:
Deposited On:
09 May 2022 12:24
Refereed?:
Yes
Published?:
In Press
Last Modified:
24 May 2022 00:40