Premorbid risk markers for chronic fatigue syndrome in the 1958 British birth cohort

Clark, C and Goodwin, L and Stansfeld, SA and Hotopf, M and White, PD (2011) Premorbid risk markers for chronic fatigue syndrome in the 1958 British birth cohort. The British journal of psychiatry : the journal of mental science, 199 (4). pp. 323-329.

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Abstract

Background Little is known about the aetiology of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME); prospective studies suggest a role for premorbid mood disorder. Aims To examine childhood and early adult adversity, ill health and physical activity as premorbid risk markers for CFS/ME by 42 years, taking psychopathology into account. Method Data were from the 1958 British birth cohort, a prospective study from birth to 42 years (n = 11 419). The outcomes were self-reported CFS/ME (n = 127) and operationally defined CFS-like illness (n = 241) at 42 years. Results Adjusting for psychopathology, parental physical abuse (odds ratio (OR) = 2.10, 95% CI 1.16–3.81), childhood gastrointestinal symptoms (OR = 1.58, 95% CI 1.00–2.50) and parental reports of many colds (OR = 1.65, 95% CI 1.09–2.50) were independently associated with self-reported CFS/ME. Female gender and premorbid psychopathology were the only risk markers for CFS-like illness, independent of comorbid psychopathology. Conclusions This confirms the importance of premorbid psychopathology in the aetiological pathways of CFS/ME, and replicates retrospective findings that childhood adversity may play a role in a minority.

Item Type:
Journal Article
Journal or Publication Title:
The British journal of psychiatry : the journal of mental science
ID Code:
169149
Deposited By:
Deposited On:
21 Apr 2022 10:50
Refereed?:
Yes
Published?:
Published
Last Modified:
03 May 2022 03:34