Recent advances in the catalytic generation of N-Acyliminium ions and subsequent applications

Basson, Ashley and McLaughlin, Mark (2022) Recent advances in the catalytic generation of N-Acyliminium ions and subsequent applications. Tetrahedron, 114: 132764. ISSN 0040-4020

Abstract

N-acyliminium ions are highly electrophilic reactive intermediates which allow functionalization α to an amide or carbamate. Traditionally accessed using stoichiometric quantities, catalytic generation continually offers greater control and selectivity. This review provides an overview of the most recent advancements in catalytic access to N-acyliminium ions using Brønsted acid, Lewis acid, photoredox and redox mediated pathways.