Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells

Quincozes-Santos, André and Abib, Renata Torres and Leite, Marina Concli and Bobermin, Daiane and Bambini-Junior, Victorio and Gonçalves, Carlos-Alberto and Riesgo, Rudimar and Gottfried, Carmem (2008) Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells. Molecular and Cellular Biochemistry, 314 (1-2). pp. 59-63. ISSN 0300-8177

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Abstract

We investigated the effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 glioma cells, considering the putative involvement of astroglial cells in neuropsychiatric disorders. In the presence of high experimental doses of risperidone, C6 cells become stellate, with process-bearing cells and partial retraction of the cell body followed by detachment from the adhesion surface with practically no cell death. These results indicate that risperidone is able to interfere with C6 cell adhesion without toxic effects. RhoA activator LPA prevented the effects of risperidone on cell morphology. From 6 h risperidone induced a statistically significant increment of about 80% in S100B secretion. These data contribute to the proposal that glial cells are targets of risperidone, which could be involved in the therapeutic response of risperidone to improve autism symptoms.

Item Type:
Journal Article
Journal or Publication Title:
Molecular and Cellular Biochemistry
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1308
Subjects:
ID Code:
168532
Deposited By:
Deposited On:
12 Apr 2022 12:50
Refereed?:
Yes
Published?:
Published
Last Modified:
12 Apr 2022 12:50