Altered aquaporins in the brains of mice submitted to intermittent hypoxia model of sleep apnea

Baronio, Diego and Martinez, Denis and Fiori, Cintia Zappe and Bambini-Junior, Victorio and Forgiarini, Luiz Felipe and Pase da Rosa, Darlan and Kim, Lenise Jihe and Cerski, Marcelle Reesink (2013) Altered aquaporins in the brains of mice submitted to intermittent hypoxia model of sleep apnea. Respiratory physiology & neurobiology, 185 (2). pp. 217-221. ISSN 1569-9048

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Rostral fluid displacement has been proposed as a pathophysiologic mechanism of both central and obstructive sleep apnea. Aquaporins are membrane proteins that regulate water transport across the cell membrane and are involved in brain edema formation and resolution. The present study investigated the effect of intermittent hypoxia (IH), a model of sleep apnea, on brain aquaporins. Mice were exposed to intermittent hypoxia to a nadir of 7% oxygen fraction. Brain water content, Aquaporin-1 and Aquaporin-3 were measured in the cerebellum and hippocampus. Hematoxylin-eosin and immunohistochemistry stainings were performed to evaluate cell damage. Compared to the sham group, the hypoxia group presented higher brain water content, lower levels of Aquaporin-1 and similar levels of Aquaporin-3. Immunoreactivity to GFAP and S100B was stronger in the hypoxia group in areas of extensive gliosis, compatible with cytotoxic edema. These findings, although preliminary, indicate an effect of IH on aquaporins levels. Further investigation about the relevance of these data on the pathophysiology of OSA is warranted.

Item Type:
Journal Article
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Respiratory physiology & neurobiology
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Copyright © 2012 Elsevier B.V. All rights reserved.
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12 Apr 2022 14:35
Last Modified:
21 Sep 2023 03:15