Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

Bambini-Junior, Victorio and Nunes, Gustavo Della Flora and Schneider, Tomasz and Gottfried, Carmem (2014) Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring". Science, 346 (6206). p. 176. ISSN 0036-8075

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Abstract

Tyzio et al. (Reports, 7 February 2014, p. 675) reported that bumetanide restored the impaired oxytocin-mediated γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery in animal models of autism, ameliorating some autistic-like characteristics in the offspring. However, standard practices in the study of these models, such as the use of sex-dimorphic or males-only analyses and implementation of tests measuring social behavior, are lacking to definitely associate their findings to autism.

Item Type:
Journal Article
Journal or Publication Title:
Science
Additional Information:
Copyright © 2014, American Association for the Advancement of Science.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1000
Subjects:
ID Code:
168525
Deposited By:
Deposited On:
12 Apr 2022 14:40
Refereed?:
Yes
Published?:
Published
Last Modified:
12 Apr 2022 14:40