The Impact of Neuroimmune Alterations in Autism Spectrum Disorder

Gottfried, Carmem and Bambini-Junior, Victorio and Francis, Fiona and Riesgo, Rudimar and Savino, Wilson (2015) The Impact of Neuroimmune Alterations in Autism Spectrum Disorder. Frontiers in Psychiatry, 6. ISSN 1664-0640

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Autism spectrum disorder (ASD) involves a complex interplay of both genetic and environmental risk factors, with immune alterations and synaptic connection deficiency in early life. In the past decade, studies of ASD have substantially increased, in both humans and animal models. Immunological imbalance (including autoimmunity) has been proposed as a major etiological component in ASD, taking into account increased levels of pro-inflammatory cytokines observed in postmortem brain from patients, as well as autoantibody production. Also, epidemiological studies have established a correlation of ASD with family history of autoimmune diseases; associations with major histocompatibility complex haplotypes and abnormal levels of immunological markers in the blood. Moreover, the use of animal models to study ASD is providing increasing information on the relationship between the immune system and the pathophysiology of ASD. Herein, we will discuss the accumulating literature for ASD, giving special attention to the relevant aspects of factors that may be related to the neuroimmune interface in the development of ASD, including changes in neuroplasticity.

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Journal Article
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Frontiers in Psychiatry
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Deposited On:
15 Jul 2022 10:00
Last Modified:
21 Sep 2023 03:15